Diabetic Ketoacidosis: Brain Morphology and Cognition

Completed

Conditions studied: Diabetic Ketoacidosis

In brief

The purpose of this study is to assess brain and memory changes in patients with uncontrolled diabetes (a condition called diabetic ketoacidosis (DKA))

Key facts

Study ID

NCT02443415

Run by

Emory University

People needed

45

Starts

2015-02-01

Expected to finish

2017-10-01

Last updated by the study team

2017-10-25

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Type 1 or type 2 diabetes with diabetic ketoacidosis (DKA)
• Age 18-50 years
• Newly diagnosed or history of noncompliance with insulin therapy as precipitating cause of DKA
• No significant medical or surgical illness as precipitating cause of DKA

You may not qualify if…

• Significant medical/surgical illness as precipitating cause of DKA (i.e. myocardial infarction, major surgery)
• Associated significant medical or surgical condition within 6 months history
• History of hypoglycemia unawareness
• History of seizures, ischemic stroke or hemorrhage, and severe head trauma
• History of symptomatic stenosis of major intracranial vessels
• Dementia (mini-mental state examination (MMSE) score (r ≤ 24) or inability to cooperate)
• Liver or renal failure or transplant
• Severe hypertension (systolic blood pressure (BP) >160 mm Hg and/or diastolic BP >100 mm Hg or subjects taking ≥ 2 antihypertensive medications)
• Malignancy
• Current recreational drug or alcohol abuse
• Magnetic resonance imaging (MRI) exclusions: any metal and bio-implants not compatible with 3 Tesla MRI, claustrophobia

Where it is running

• Grady Health System — Atlanta, Georgia, United States
• Emory University School of Medicine — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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