Non-invasive Measurement of Cerebral Dynamic Autoregulation

Completed · Not applicable

Conditions studied: Stroke

In brief

The overall objective of this study is to evaluate the use of diffuse correlation spectroscopy to non-invasively measure dynamic cerebral autoregulation in subjects with vascular risk factors. Optical cerebral blood flow measurements will be correlated with changes in arterial blood pressure to assess how CBF is maintained in response to changes in ABP, and will be compared to transcranial doppler reference measurements.

Key facts

Study ID

NCT02442856

Run by

University of Pennsylvania

People needed

21

Starts

2015-06-01

Expected to finish

2020-03-01

Last updated by the study team

2020-08-14

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than or equal to 50 years
• Positive history of at least one of the following vascular disk factors: hypertension, diabetes, hyperlipidemia, coronary artery disease, atrial fibrillation, prior myocardial infarct, transient ischemic attack, or history of smoking

You may not qualify if…

• Vascular risk factor subjects:
• Pregnant women
• Prisoners
• Prior neurosurgical procedure or traumatic brain injury, including hemicraniectomy or other skull defect
• Prior history of ischemic or hemorrhagic stroke
• Prior lower extremity amputation
• Peripheral vascular disease

Where it is running

• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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