CellulaR Injury and Preterm Birth
Completed
Conditions studied: Preterm Birth
In brief
The goal of this study is to examine how cellular dysfunction can lead to preterm birth. Women with singleton pregnancies with spontaneous preterm labor, preterm premature rupture of membranes, and cervical insufficiency (20 to 36-6/7 weeks gestation), and term deliveries (greater than 38 weeks) will be enrolled. Medical/obstetric history and pregnancy outcomes will be recorded. Maternal blood, urine and cervical cells (enrollment); cord blood and placental biopsy (delivery) will be collected.
Key facts
- Study ID
- NCT02441335
- Run by
- University of Pennsylvania
- People needed
- 705
- Starts
- 2015-01-01
- Expected to finish
- 2019-08-01
- Last updated by the study team
- 2019-10-07
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- 18-45 years of age
- Singleton pregnancy between 20 0/7 and 36 6/7 weeks gestational age who is admitted with preterm labor or cervical insufficiency (greater than 2 cm dilation) or Preterm Premature Rupture of Membranes
You may not qualify if…
- Multiple gestation
- Fetal chromosomal abnormality
- Major fetal anomaly
- Intra-uterine fetal demise
- Gestational hypertension/preeclampsia
- Controls:
- Inclusion Criteria:
- 18-45 years of age
- Singleton pregnancy that delivers at term (38 to 41 weeks gestational age)
- Admitted to the hospital with spontaneous labor (regular contractions, cervical dilation) or spontaneous rupture of membranes
- Exclusion Criteria:
- Multiple gestation
- Fetal chromosomal abnormality
- Major fetal anomaly
- Intra-uterine fetal demise
- Intra-uterine growth restriction
- Gestational hypertension/preeclampsia
- Clinical chorioaminionitis
- Induction of labor
- Elective c-section
Where it is running
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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