Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression

Completed · Not applicable

Conditions studied: Major Depressive Disorder

In brief

The specific focus of this study is to gather data regarding the effects of a psychological therapy known as Problem Solving Therapy (PST) on cerebral blood flow (CBF), cortical gray matter (GM) atrophy, subcortical white matter (WM) lesion burden, and measures of cognitive function in subjects with Late Life Major Depressive Disorder (LLD). This research goal will be achieved by recruiting 110 individuals over the age of 65 with LLD. The primary outcomes will be change in CBF, change in GM atrophy, change in WM lesion, change in cognitive function, and change in depression severity from baseline to the end of 12 weeks of PST.

Key facts

Study ID

NCT02440815

Run by

University of California, San Francisco

People needed

108

Starts

2015-11-01

Expected to finish

2021-07-28

Last updated by the study team

2021-08-04

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Current DSM-IV diagnosis of MDD, unipolar type, without psychotic features and 6 weeks minimum duration of current depressive episode.
• Moderate severity of depression using the Hamilton Depression Rating Scale (HDRS > 20).
• English speaking, male or female
• 65 years of age or older
• Good general health
• Able to give informed consent

You may not qualify if…

• Antidepressant use or psychotherapy within the past 6 weeks or electroconvulsive therapy within the past 6 months.
• Recent history (<6 months) of substance or alcohol abuse or dependence (DSM-IV criteria).
• Use of cognitive enhancing medications.
• Current diagnosis of Post-Traumatic Stress Disorder or other Axis 1 psychiatric disorder.
• Neurological diseases (e.g., Parkinson's disease, epilepsy, cortical stroke, Alzheimer's disease, traumatic brain injury) or dementia.
• History of surgical procedures affecting study outcomes.
• Contraindications for MR exam, i.e., no claustrophobia, no paramagnetic metal implants, able to fit in the MRI machine comfortably (BMI ≤ 38).
• Acute or uncontrolled medical illness or medication use impacting cognitive function.

Where it is running

• University of California, San Francisco, Langley Porter Psychiatric Institute — San Francisco, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.