Study of Phosphatidylinositol-3-kinase (PI3K) Inhibitor Idelalisib (GS-1101) in Waldenström Macroglobulinemia

Stopped early · Phase 2

Conditions studied: Waldenstrom's Macroglobulinemia

In brief

This research study is evaluating a drug called idelalisib (formerly known as GS-1101 or CAL-101) as a possible treatment for Waldenstrom's Macroglobulinemia (WM).

Key facts

Study ID: NCT02439138
Run by: Dana-Farber Cancer Institute
People needed: 5
Starts: 2015-10-01
Expected to finish: 2016-04-01
Last updated by the study team: 2017-01-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Participants must meet the following criteria on screening examination to be eligible to participate in the study:
Clinicopathological diagnosis of Waldenstrom's Macroglobulinemia and meeting criteria for treatment using consensus panel criteria from the Second International Workshop on Waldenstrom's macroglobulinemia (Owen 2003; Kyle 2003).
Measurable disease, defined as presence of serum immunoglobulin M (IgM) with a minimum IgM level of > 2 times the upper limit of normal of each institution is required.
Have received at least one prior therapy for WM.
Age ≥18 years.
ECOG performance status <2 (see Appendix A.).
Participants must have normal organ and marrow function as defined below:
Absolute neutrophil count > 1,000/mm3
Platelets > 50,000/mm3
Hemoglobin > 8 g/dL
Total bilirubin ≤1.5 mg/dL or < 2 mg/dL if attributable to hepatic infiltration by neoplastic disease
AST (SGOT) and ALT (SGPT) < 2.5 X institutional upper limit of normal
Creatinine ≤ 2 mg/dL
Not on any active therapy for other malignancies with the exception of topical therapies for basal cell or squamous cell cancers of the skin.
Females of childbearing potential (FCBP) must agree to use two reliable forms of contraception simultaneously or have or will have complete abstinence from heterosexual intercourse during the following time periods related to this study:
while participating in the study; and 2) for at least 28 days after discontinuation from the study. Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy. FCBP must be referred to a qualified provider of contraceptive methods if needed.
Able to adhere to the study visit schedule and other protocol requirements.
Ability to understand and the willingness to sign a written informed consent document

You may not qualify if…

Any serious medical condition, laboratory abnormality, uncontrolled intercurrent illness, or psychiatric illness/social condition that would prevent the participant from signing the informed consent form
Concurrent use of any other anti-cancer agents or treatments or any other study agents
Prior exposure to idelalisib
Prior or ongoing clinically significant illness, medical condition, surgical history, physical finding, ECG finding, or laboratory abnormality that, in the investigator's opinion, could affect the safety of the patient; alter the absorption, distribution, metabolism or excretion of Idelalisib; or impair the assessment of study results
Grade > 2 toxicity (other than alopecia) continuing from prior anti-cancer therapy
Known central nervous system lymphoma
Significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of screening
New York Heart Association classification III or IV heart failure.
Malabsorption syndrome, disease significantly affecting gastrointestinal function, or resection of the stomach or small bowel, ulcerative colitis, symptomatic inflammatory bowel disease, or partial or complete bowel obstruction.
Known history of Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), and/or Hepatitis C Virus (HCV) infection
Lactating or pregnant women
Inability to swallow capsules
History of non-compliance to medical regimens
Unwilling or unable to comply with the protocol

Where it is running

Dana Farber Cancer Institute — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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