Texas Family Health Patterns: A Study Across Generations
Completed
Conditions studied: Alcohol and Other Drug Use Disorders
In brief
The researchers are studying factors that may increase the risk for alcohol and drug use in individuals who do not have any problems with these substances. This study will be looking at health behaviors in young adults compared to their family's health behaviors and lifestyle. The investigators plan to study genetic differences in people with and without a family history of alcoholism. The researchers hope to learn how a family history of alcoholism, early life adversity and different genotypes shape personal characteristics associated with a risk for alcoholism.
Key facts
- Study ID
- NCT02438254
- Run by
- The University of Texas Health Science Center at San Antonio
- People needed
- 139
- Starts
- 2014-09-01
- Expected to finish
- 2016-09-01
- Last updated by the study team
- 2017-02-28
Who can join
Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Male or female sex
- Age 18-29 years
- Normal health based on routine history and physical
- Willingness to provide a DNA sample
- No required CNS-acting medications, history of neurological impairment, or diabetes mellitus
- Normal color vision
- Normal intelligence based on Shipley Institute of Living verbal scale score ≥ 20 (John \& Rattan, 1992)
- Negative urine drug screen at entry and each lab visit (icup, Alcopro, Knoxville, TN) and alcohol breath test (AlcoMate CA2000, KHN Solutions, San Francisco)
- Volunteers must have been raised by at least one biological parent and have knowledge of and contact with same
You may not qualify if…
- Pregnancy
- Any failure to meet inclusion criteria
- Rearing by other than a biological parent
- Suspected maternal alcoholism during pregnancy with proband, determined by interview with subject or parent
- AUDIT score > 12
- Inability of parent to provide credible report of family alcohol use patterns for two generations
- Current Axis I disorder by DIS-IV, excepting past depression or abuse of alcohol or drugs (all > 60 days)
- Axis II disorder in Clusters A or C by SCID II. AXIS II symptoms in Cluster B are not exclusionary because antisocial and behavioral undercontrol variables related to substance use disorders overlap with Cluster B symptoms. Past abuse of alcohol and other substances is not exclusionary in order to allow a wide range of intake while still avoiding severe consequences of intake history.
Where it is running
- University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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