An Enhanced Protein (Dairy) Weight Loss Intervention for Dynapenic Obesity: Impact on Muscle Quality and Composition
Completed · Not applicable
Conditions studied: Dynapenia, Obesity
In brief
The purpose of the trial is to assess the effects of combining regular, generous intakes of high quality protein (primarily from dairy and other animal source proteins) with calorie restriction and low-intensity exercise on muscle quality and muscle adipose infiltration (along with bone mineral density \[BMD\] and a number of secondary outcomes) in frail, obese, older adults participating in a 6 month intervention. The investigators will compare these effects to those of a traditional control regimen of calorie restriction and low-intensity exercise over the same duration.
Key facts
- Study ID
- NCT02437643
- Run by
- Duke University
- People needed
- 81
- Starts
- 2015-08-17
- Expected to finish
- 2018-10-15
- Last updated by the study team
- 2018-11-07
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- BMI >30;
- SPPB score of ≥4 to <10;
- GFR <45 mL/min
You may not qualify if…
- Body weight >495 lbs. (BodPod limits);
- estimated glomerular filtration rates (eGFR) less than 45 mL/min;
- symptomatic cardiac disease;
- receiving chemotherapy;
- hemophilia;
- presence of unstable or symptomatic life-threatening illness;
- neurological disease or disorder causing functional impairments;
- inability to walk,
- dementia;
- prescription weight loss medications;
- use of monamine oxidase inhibitors (MAOIs); or
- primary medical provider advises against participation.
Where it is running
- Duke University Medical Center — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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