Trial of the Treatment of Chronic Laryngitis With Amitryptiline

Stopped early · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Laryngeal Diseases, Chronic Laryngeal Neuropathy

In brief

The study will compare the effectiveness of amitriptyline versus placebo (inactive medication) in treating chronic laryngitis.

Key facts

Study ID

NCT02434523

Run by

Boston Medical Center

People needed

30

Starts

2013-09-01

Expected to finish

2015-01-01

Last updated by the study team

2016-11-30

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 or older and able to consent for themselves.
• Structural pathology such as tumor previously ruled out using flexible laryngoscopy.
• Able to speak and read the English language.
• Failed a trial of a proton pump inhibitor for the treatment of gastopharyngeal reflux.
• Women under 55 years of age who may become pregnant must have a negative pregnancy test and agree to barrier or hormonal methods of contraception during the study.

You may not qualify if…

• Environmental allergies.
• Smoking within past 5 years.
• Using ginko bilboa (or unwilling to cease using it).
• Current upper respiratory infections.
• Use of narcotics (e.g. oxycodone, methadone).
• Any prior history of amitryptiline use.
• Use of monoamine oxidase inhibitors (MAOIs) within the past 4 weeks (selegiline, phenelzine, tranylcypromine, isocarboxazid, rasagiline, phenelzine sulfate, selegiline hydrochloride, rasagiline mesylate, tranylcypromine sulfate).
• History of urinary retention.
• Any history of major depressive disorder.
• Any prior history of allergy to a tricyclic antidepressant.
• Current diagnosis of gastroesophageal reflux (GERD).
• For women 18-55 years of age without history of menopause: currently nursing or pregnant, plans to become pregnant, or unwillingness to utilize contraception (barrier or hormonal methods).

Where it is running

• Boston Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.