Neurophysiological and Immunological Effects of the Transition From Combustible to Electronic Cigarettes

Completed · Not applicable

Conditions studied: Tobacco Smoking, Nicotine Dependence

In brief

The objective of this study is to examine the cognitive, immunological, and neurophysiological effects of transitioning from tobacco cigarettes to electronic cigarettes. The central hypothesis of this study is that this transition will be accompanied by a decrease in peripheral inflammation, which will lead to significant changes in the neurocircuitry underlying interoception and appetite.

Key facts

Study ID: NCT02433015
Run by: Laureate Institute for Brain Research, Inc.
People needed: 27
Starts: 2015-01-01
Expected to finish: 2016-09-24
Last updated by the study team: 2017-06-28

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

current cigarette smokers who have smoked for at least one year
right-handed adults
able to provide written informed consent

You may not qualify if…

use of anticonvulsant, stimulant, or antipsychotic medication for 3 weeks prior to scanning
any medical conditions or medications likely to influence cerebral blood flow or neurological function including cardiovascular, respiratory, endocrine and neurological diseases
any history of drug (other than nicotine) or alcohol abuse within 1 year
current pregnancy or breast feeding
primary language other than English
meeting general MRI exclusion criteria such as magnetic implants or claustrophobia
Past history of any axis I psychiatric condition, other than major depressive disorder and post-traumatic stress disorder
Current major depression or post-traumatic stress disorder
Serious suicidal ideation

Where it is running

Laureate Institute for Brain Research — Tulsa, Oklahoma, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.