Safety and Durability of Sirolimus for Treatment of LAM

Recruiting now

Conditions studied: Lymphangioleiomyomatosis

In brief

The MIDAS study aims to follow male and female LAM patients who are currently taking, have previously failed or been intolerant of, or may (at some time in the future) take mTOR inhibitors (sirolimus or everolimus) as part of their clinical care. Adult female TSC patients may also enroll, with or without lung cysts.

Key facts

Study ID

NCT02432560

Run by

University of Cincinnati

People needed

600

Starts

2015-03-01

Expected to finish

2025-07-31

Last updated by the study team

2024-12-24

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female or male, age 18 or over
• Diagnosis of LAM based on ATS/JRS criteria
• Signed and dated informed consent
• On chronic therapy, newly treated or may be considered for therapy with mTOR inhibitors or previously intolerant of or having failed mTOR inhibitor therapy

You may not qualify if…

• Inability to attend at least one RLD Clinic visit per year
• Inability to give informed consent
• Inability or unwillingness to perform pulmonary function testing

Where it is running

• National Jewish Health — Denver, Colorado, United States (enrolling)
• Washington University School of Medicine — St Louis, Missouri, United States (enrolling)
• University of Rochester Medical Center — Rochester, New York, United States (enrolling)
• Mayo Clinic Jacksonville — Jacksonville, Florida, United States (enrolling)
• Emory University School of Medicine — Atlanta, Georgia, United States (enrolling)
• Stanford University Medical Center — Stanford, California, United States (enrolling)
• Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)
• University of Michigan — Ann Arbor, Michigan, United States (enrolling)
• Cleveland Clinic — Cleveland, Ohio, United States
• Oregon Health and Science University — Portland, Oregon, United States
• University of Pennsylvania Medical Center — Philadelphia, Pennsylvania, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• University of Texas Southwestern Medical Center — Dallas, Texas, United States
• University of Texas Health Center — Houston, Texas, United States
• University of Utah School of Medicine — Salt Lake City, Utah, United States
• Swedish Medical Center — Seattle, Washington, United States
• Loyola University Medical Center, Chicago — Maywood, Illinois, United States
• Mayo Clinic Rochester — Rochester, Minnesota, United States
• University of Cincinnati — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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