Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients
Completed · Phase 4 · Has a placebo group
Conditions studied: Wounds and Injuries, Rib Fractures
In brief
This study will evaluate the effectiveness of ketamine infusions in the management of acute pain resulting from broken ribs suffered following a blunt trauma. Half of patients will receive the institutional standard of care and a placebo infusion (no active medication). The other half of patients will receive the institutional standard of care and a ketamine infusion. All subjects and staff will be blinded as to whether they are receiving placebo or ketamine.
Key facts
- Study ID
- NCT02432456
- Run by
- Medical College of Wisconsin
- People needed
- 153
- Starts
- 2015-09-01
- Expected to finish
- 2018-08-01
- Last updated by the study team
- 2020-02-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age greater than 18 years
- rib fractures following recent trauma with admission to Froedtert Memorial Lutheran Hospital
You may not qualify if…
- history of adverse reaction / intolerance to ketamine therapy
- elevated intracranial pressure
- ischemic heart disease defined as active acute coronary syndrome
- severe, poorly controlled hypertension (Systolic Blood Pressure > 200 mmHg or Diastolic Blood Pressure > 100 mmHg)
- current opiate agonist/antagonist therapy
- concurrent use of monoamine oxidase inhibitors (MAOIs)
- chronic pain or opioid tolerance defined as > 3 weeks of >30mg oral morphine equivalents per day
- current substance abuse with opiates (prescription and/or heroin) or ketamine
- Glasgow Coma Scale <13
- Intubation on arrival or need for urgent intubation on arrival
- inability to delineate pain and/or appropriately communicate with staff
- history of psychosis
- three or more psychotropic medications
- active delirium
- glaucoma
- pregnancy
- prisoners
Where it is running
- Froedtert Memorial Lutheran Hospital — Milwaukee, Wisconsin, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.