Eovist vs. Dotarem Healthy Volunteer MRI

Completed · Phase 4

Conditions studied: Transient Severe Arterial Phase Motion

In brief

The purpose of this study is to evaluate changes in volunteer breath-holding capacity in response to gadoxetate disodium (Eovist) administration, compared with saline, and gadoterate dimeglumine (Dotarem). Healthy volunteers will be recruited from three study sites. These subjects will be given three, blinded, randomized injections while undergoing an MRI of their liver and holding their breath. During the scan, the subjects' oxygen saturation and heart rate will be closely monitored. Following the scan, the subjects will complete a questionnaire regarding the breath hold.

Key facts

Study ID

NCT02431598

Run by

Duke University

People needed

44

Starts

2015-06-01

Expected to finish

2015-09-01

Last updated by the study team

2017-04-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• normal renal function (serum eGFR >60)

You may not qualify if…

• renal impairment
• allergy to gadolinium-based contrast
• metallic implanted devices
• claustrophobia
• pregnant and lactating females

Where it is running

• Duke Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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