Safety and Pharmacokinetic Study of HIV Prophylaxis Using Antiretroviral Intravaginal Rings in Healthy Women

Completed · Early Phase 1

Conditions studied: Human Immunodeficiency Virus (HIV) Prophylaxis

In brief

This study will evaluate the hypothesis that intravaginal rings (IVRs) can safely and in a sustained fashion, deliver the antiretroviral (ARV) drugs - tenofovir disoproxil fumarate (TDF), emtricitabine (FTC), and maraviroc (MVC), in healthy women when used in the following drug combinations: 1) TDF ("Single" IVR); 2) TDF-FTC ("Dual" IVR) and; 3) TDF-FTC-MVC ("Triple" IVR). TDF = tenofovir disoproxil fumarate; FTC = emtrcitabine; MVC = maraviroc

Key facts

Study ID

NCT02431273

Run by

Auritec Pharmaceuticals

People needed

10

Starts

2015-06-01

Expected to finish

2016-12-01

Last updated by the study team

2019-07-02

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Provides written informed consent
• Healthy female 18-45 years of age
• HIV negative per subject report and results of screening examination
• Negative for sexually transmitted diseases in the past 3 months and at screening exam
• No history of genital herpes simplex I or II per subject report
• Currently using contraception with plans to continue throughout the study duration or having sex with females only
• Pre-menopausal with a regular menstrual cycle with at least 21 days between menses and no history of intermenstrual bleeding or with suppressed menstrual cycle by hormonal contraception such as Depo-Provera or continuous oral contraceptive agents
• Subjects must agree to abstain from vaginal, anal, and oral sex throughout the first week of each dosing period and then use condoms for vaginal/rectal intercourse until after the final visit for use of each IVR
• Subjects must agree to not douche or use any vaginal product other than the Single, Dual and Triple ARV IVRs, including lubricants, feminine hygiene products, and vaginal drying agents throughout the dosing period and until after the final visit
• Subjects must agree to blood draws and vaginal exams throughout the course of the study

You may not qualify if…

• HIV positive by subject report or results of screening examination
• Positive history for autoimmune disease
• Abnormal genital exam defined as grade 1 or higher adverse event by DAIDS genital AE grading table
• Abnormal ALT or AST or Hepatitis B infection
• Active vaginal infection as determined by site IoR
• Abnormal renal function (defined as a creatinine clearance of <50mL/min/1.73 m2)
• Pregnant or less than 6 months post-partum or current lactation
• Current use of an IVR (i.e., Nuvaring, Estring, Femring)
• History of TDF, FTC, and MVC use and/or adverse reaction to any of these drugs
• History of adverse reaction to silicone
• History of toxic shock syndrome
• Currently receiving chemotherapy or immunosuppressive agents
• Use of investigative drugs within 30 days or 5 half-lives
• Currently using or suspected to be using non-therapeutic injection drugs

Where it is running

• University of Texas Medical Branch — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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