Timing of Direct Current Cardioversion (DCC) in Patients Undergoing Ablation of Persistent/Permanent Atrial Fibrillation
Completed · Not applicable
Conditions studied: Atrial Fibrillation
In brief
The purpose of this study is to compare which strategy is superior in patients with persistent/permanent atrial fibrillation (AF) undergoing ablation, direct current cardioversion (DCC) prior to empirical pulmonary vein isolation (PVI) ; or pulmonary vein isolation (PVI)ablation in atrial fibrillation then Direct current cardioversion (DCC) if the patient remains in atrial fibrillation.
Key facts
- Study ID
- NCT02429648
- Run by
- The Cleveland Clinic
- People needed
- 90
- Starts
- 2009-06-01
- Expected to finish
- 2015-08-01
- Last updated by the study team
- 2017-02-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Persistent or long standing persistent AF resistant to anti-arrhythmic medication. Must have been present for more than 2 months
- Therapeutic anticoagulation for at least three weeks prior to initiation of therapy, or TEE performed prior to the procedure
- Age >= 18 years old. (Females must be either post-menopausal >12 months, practicing a protocol-acceptable method of birth control
- Scheduled for Pulmonary Vein Isolation
- Amiodarone will be stopped at least 3 months prior to procedure
You may not qualify if…
- Reversible causes of AF such as pericarditis, hyperthyroidism
- Presently with Valvular Heart disease requiring surgical intervention
- Presently with coronary artery disease requiring surgical intervention
- Early Post-operative AF (within three months of surgery)
- Previous MAZE or left atrial instrumentation
- Life expectancy <= 2 years
- Social factors that would preclude follow up or make compliance difficult.
- Contraindication to the use of anti-arrhythmic medications and/or coumadin and heparin
- Enrollment in another investigational drug or device study
- Patients with severe pulmonary disease
- Documented intra-atrial thrombus, tumor, or another abnormality which precludes catheter introduction
Where it is running
- Cleveland Clinic — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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