Effect of Desipramine on Genioglossus Muscle Activity in Healthy Adults Study A

Completed · Phase 2 · Has a placebo group

Conditions studied: Sleep Apnea, Obstructive

In brief

Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal participants. Until recently, the search for medicines to activate pharyngeal muscles in sleeping humans has been discouraging. However, exciting new animal research has shown that drugs with noradrenergic and antimuscarinic effects can restore pharyngeal muscle activity to waking levels. In this protocol the investigators will test the effect of desipramine (a tricyclic antidepressant with strong noradrenergic and antimuscarinic effects) on genioglossus muscle activity (EMG GG) during sleep in healthy control participants.

Key facts

Study ID
NCT02428478
Run by
Brigham and Women's Hospital
People needed
17
Starts
2015-03-01
Expected to finish
2016-03-01
Last updated by the study team
2017-03-30

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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