Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Liver Cirrhosis, Muscle Cramps

In brief

Muscle cramps are common in patients with liver disease and associated with significantly diminished quality of life. Patients with cirrhosis often experience muscle cramps with varied frequency and severity. The exact mechanisms by which they occur remain unclear, although a number of pathophysiological events unique to liver disease may contribute. Clinical studies have identified alterations in 3 areas: nerve function, energy metabolism, and plasma volume/electrolytes (1) Orphenadrine is an anticholinergic drug with prominent central nervous system (CNS) and peripheral actions used to treat painful muscle spasms and other similar conditions. The combination of anticholinergic effects and CNS penetration make orphenadrine useful for pain of all etiologies, including from: radiculopathy, muscles, and headaches. \[3,4\]

Key facts

Study ID

NCT02423395

Run by

Sherief Abd-Elsalam

People needed

100

Starts

2015-01-01

Expected to finish

2028-12-01

Last updated by the study team

2019-06-07

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Cirrhosis
• Muscle cramps( ≥3 cramps per week )

You may not qualify if…

• • Allergy to orphenadrine
• Renal impairment
• Pregnant and lactating women
• Peripheral vascular disease
• Peripheral neuropathy
• Medications as calcium channel blockers, conjugated estrogens and naproxen. Glaucoma Prostatic enlargement

Where it is running

• Tanta university hospital — Tanta, Egypt (enrolling)

Full record on ClinicalTrials.gov

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