Imaging Acquisition and Analysis Methods for Optimization of MRI Radiation Oncology Simulation and Response Assessment

Recruiting now

Conditions studied: Radiation Therapy

In brief

Magnetic resonance imaging (MRI) is currently one of the standard diagnostic imaging methods used to diagnose tumor stage before treatment in the Radiation Oncology Department. It is also used to check responses to radiation after treatment. However, MRI isn't traditionally used in planning for radiation treatment or in checking treated tumor and tissue changes during radiation treatment. The goal is to find out the possible benefits of MRI imaging techniques in these settings of radiation treatment. The research aims are to study the possibility of using devices with new abilities such as the MR-Linac. The MR-Linac combines a radiation treatment machine with a diagnostic MRI scanner. This device will improve the quality of MRI-guided radiation treatment. The MR-Linac has functions that are currently not available in other combined imaging and radiation delivery devices. The MR-Linac does not provide additional imaging capabilities that are not currently available in other imaging devices. Participating in this study would NOT change the current treatment plans, this will allow the investigators to use the MRI methods in research and future patient care.

Key facts

Study ID

NCT02422550

Run by

Memorial Sloan Kettering Cancer Center

People needed

837

Starts

2015-04-09

Expected to finish

2027-04-01

Last updated by the study team

2026-03-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women age 18 or older

You may not qualify if…

• Anyone who would be normally excluded from undergoing an MRI examination as per Memorial Hospital for Cancer and Allied Diseases Screening Questionnaire
• Participants/volunteers with a pacemaker, aneurysm clip or any other condition that would warrant avoidance of a strong magnetic field
• Female participants/volunteers who are pregnant or nursing
• Participants/Volunteers who are unable to comply or complete the MRI exam due to claustrophobia or high levels of anxiety
• Participants/Volunteers from the vulnerable population, as defined by 45 CFR 46.
• Participants at higher risk due to age, frailty, or the emergent nature of their condition.

Where it is running

• Memorial Sloan Kettering Basking Ridge (Consent only) — Basking Ridge, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Monmouth (Consent only) — Middletown, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Bergen (Consent only ) — Montvale, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Commack (Consent Only) — Commack, New York, United States (enrolling)
• Memorial Sloan Kettering Westchester (Consent only) — Harrison, New York, United States (enrolling)
• Memorial Sloan Kettering Cancer Center — New York, New York, United States (enrolling)
• Memorial Sloan Kettering Nassau (Consent only) — Uniondale, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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