Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive Symptoms

Stopped early · Not applicable

Conditions studied: Depression, Major Depressive Disorder

In brief

Ketamine has been shown to have an antidepressant effect when given intravenously in doses of 2mg/kg. Ketamine is used as a standard induction drug during general anesthesia. It is known in this instance to decrease postoperative pain. No one has studied whether or not ketamine when given in doses used during general anesthesia (0.5mg/kg intravenous) has an antidepressant effect on surgical patients who suffer from depression. The study is designed to determine whether or not a small dose of ketamine when given at the induction of anesthesia could have an antidepressant effect on surgical patients with depression.

Key facts

Study ID

NCT02422303

Run by

The University of Texas Health Science Center at San Antonio

People needed

12

Starts

2015-12-01

Expected to finish

2016-09-01

Last updated by the study team

2018-02-15

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• History of or current depression scoring five or above on Goldberg Depression Screen

You may not qualify if…

• Uncontrolled hypertension, allergy to ketamine,pregnancy

Where it is running

• University Hospital — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.