MRI Technical Development and Applications in Kidney Disease
Starting soon
Conditions studied: Chronic Kidney Diseases, Kidney Transplantation, Dialysis, Cognition Disorders
In brief
Magnetic resonance imaging (MRI), as a non-invasive and non-contrast enhanced technique, has the potential to improve patient health care and management. The overall objective of proposed project is to: 1. develop, customize, and optimize anatomic and functional MRI methods, 2. explore the use of MRI methods to study CKD and evaluate post-transplant kidneys, and 3. investigate the potential of MRI in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction. In addition to direct studies of the kidney, brain MRI studies will also be performed to identify the cerebrovascular and cognitive effects of chronic renal function deficiency and medical treatment (e.g. hemodialysis and immunosuppression). The brain and kidneys have similar vascular bed, and both are susceptible to vascular injury, which provides the pathological basis for the widely recognized association of reduced renal function with prevalent cerebrovascular diseases (CVDs) and cognitive impairment (CI). The MRI methods in the brain will be applied to explore the origins for widely observed CVDs and prevalent cognitive impairment (CI) in kidney disease patients.
Key facts
- Study ID
- NCT02421497
- Run by
- University of Minnesota
- People needed
- 180
- Starts
- 2028-06-30
- Expected to finish
- 2029-12-30
- Last updated by the study team
- 2026-04-13
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy Volunteer
You may not qualify if…
- Ferromagnetic implants
- Any foreign metal objects in the body
- History of shrapnel or shot gun injury
- Cardiac pacemakers
- Defibrillator
- Neuronal stimulator
- Magnetic aneurysm clip
- Large tattoos on the abdomen or the brain and neck
- Hip replacement
- Too large to fit in the magnet (body mass index >= 40, approx.)
- Severe claustrophobia
- Women with pregnancy
- For Specific Aim 2: Pilot Studies with Patients
- Studies for CKD
- Inclusion
- English- speaking as primary language.
- Age 45 years and older
- Able to complete an approximately 90 minute cognitive testing battery.
- Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so.
- GFR < 90 ml/min/1.73m2
- Exclusion
- Acute psychiatric illness that would impede cognitive testing
- Active chemical dependence, such as alcohol, narcotics or other drugs
- Legally blind or unable to complete cognitive tests due to visual loss or deafness
- Dialysis dependent or renal transplant recipient at time of screening or baseline
Where it is running
- Center for Magnetic Resonance Research — Minneapolis, Minnesota, United States
Full record on ClinicalTrials.gov
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