Effect of Celiac Plexus Block on Gastric Emptying and Symptoms Caused by Gastroparesis

Withdrawn before enrolling · Not applicable

Conditions studied: Gastroparesis

In brief

The investigators hypothesize that in patients with gastroparesis, gastric emptying will improve with celiac plexus block. By improving gastric emptying, symptoms related to gastroparesis including nausea, vomiting, bloating, abdominal pain, and weight loss, will also improve. In order to study this hypothesis, the investigators will enroll patients with gastroparesis who are non-responsive to the current treatments available. Patients will fill out a questionnaire to assess the severity of their symptoms then undergo Ansar testing (a non-invasive test) to measure their autonomic function respectively. Then, patients will undergo a celiac plexus block which is performed via an upper endoscopy. One week after the procedure, patients will be asked to undergo a gastric emptying study as well as repeat the Ansar testing to evaluate for any improvement in the gastric emptying and autonomic function respectively. Patient will be asked to repeat the questionnaire, one, two, three, and eight weeks after their procedure.

Key facts

Study ID

NCT02420925

Run by

Linda Nguyen

People needed

0

Starts

2014-10-01

Expected to finish

2016-06-01

Last updated by the study team

2020-08-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have gastroparesis due to idiopathic causes (including post-viral) and diabetes who have undergone a 4 hour gastric emptying study showing delayed gastric emptying
• Patients may have been or currently on therapy for their gastroparesis including metoclopramide, domperidone, macrolide antibiotics, sapropterin dihydrochloride, or pyloric botox injections can be included
• Patients who have undergone placement of electrical gastric stimulator >6 months after enrollment can be included

You may not qualify if…

• Patients with suspected mechanical obstruction resulting in delayed gastric emptying, patients chronically using narcotics (>3 times per week)
• Patients who have undergone placement of gastric electrical stimulation device within 6 months of enrollment.
• Patients with any history of small bowel obstruction and major abdominal surgeries (excluding appendectomy, cholecystectomy, Nissen fundoplication, or pelvic surgeries).

Where it is running

• Stanford Hospital and Clinics — Stanford, California, United States

Full record on ClinicalTrials.gov

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