Study of BMS-986158 in Subjects With Select Advanced Cancers

Completed · Phase 1/Phase 2

Conditions studied: Advanced Tumors

In brief

The purpose of this study is to determine the safety, tolerability, pharmacokinetics, and pharmacodynamics of BMS-986158 in subjects with select advanced cancers

Key facts

Study ID

NCT02419417

Run by

Bristol-Myers Squibb

People needed

83

Starts

2015-06-19

Expected to finish

2021-03-17

Last updated by the study team

2022-06-16

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must have select advanced cancers with specific genetic profiles
• Must have received appropriate standard of care
• At least one measurable lesion at baseline
• Expected to have life expectancy of at least 3 months
• Eastern Cooperative Oncology Group (ECOG) of 0 to 1

You may not qualify if…

• Concomitant second malignancies
• Uncontrolled or significant cardiovascular disease
• Inadequate bone marrow function
• Chronic gastrointestinal illness
• Prior treatment with Bromodomain and Extra-Terminal (BET) inhibitor
• Other protocol defined inclusion/exclusion criteria could apply

Where it is running

• City Of Hope National Medical Center — Duarte, California, United States
• University Of Colorado — Aurora, Colorado, United States
• Dana Farber Cancer Institute. — Boston, Massachusetts, United States
• Oregon Health & Science University — Portland, Oregon, United States
• Univ. Of Pa — Philadelphia, Pennsylvania, United States
• Institute for Translational Oncology Research-ITOR — Greenville, South Carolina, United States
• Nucleus Network — Melbourne, Victoria, Australia
• The Ottawa Hospital Cancer Centre — Ottawa, Ontario, Canada
• Local Institution — Lyon, France
• Local Institution — Villejuif, France
• H. Univ. Vall dHebron — Barcelona, Spain
• Centro Integral Oncologico Clara Campal — Madrid, Spain
• Clinica Universidad de Navarra — Pamplona, Spain

Full record on ClinicalTrials.gov

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