Altering Activation Patterns Post-stroke

Completed · Not applicable · Has a placebo group

Conditions studied: Stroke, Muscle Spasticity, Hemiparesis

In brief

This study evaluates a new rehabilitation approach for stroke survivors in the chronic phase of recovery in which the combination of drug therapy (cyproheptadine) and active movement practice (AMP) is used to encourage increased voluntary muscle control and strength.

Key facts

Study ID

NCT02418949

Run by

Shirley Ryan AbilityLab

People needed

96

Starts

2015-11-01

Expected to finish

2022-03-23

Last updated by the study team

2026-03-31

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Chronic, severe hand hemiparesis resulting from a single stroke (Chedoke- McMaster Stroke Assessment: Stage of Hand 2 or 3)
• Single stroke occurring at least 6 months prior to enrollment
• Spasticity
• Capacity to provide informed consent

You may not qualify if…

• Excessive pain in paretic upper limb
• Hemispatial neglect (as assessed by the Behavioral Inattention Test)
• Apraxia (as assessed by the FABERS battery)
• Botulinum toxin injection in the upper extremity within the past 6 months
• Introduction of new anti-spasticity medication within the past 6 months
• Orthopaedic impairments
• History of seizure disorder
• Other major health impairment

Where it is running

• Rehabilitation Institute of Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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