Mono-menotropins Versus rFSH Protocol on Embryo Quality

Completed · Not applicable

Conditions studied: Infertility, Fertility

In brief

This study is for couples pursuing in vitro fertilization (IVF) with preimplantation genetic screening (PGS) of embryos to achieve pregnancy. The objective of this clinical trial is to study the effect of mono-menotropins for COS versus recombinant follicle stimulating hormone (rFSH) on cleavage-stage and blastocyst embryo quality after IVF. Embryo quality parameters include conventional embryo grade, early embryo viability assessment (Eeva) time-lapse parameters, and chromosomal aneuploidy rates after PGS. This pilot study is expected to significantly contribute to optimization of treatment regimens and stimulation protocols to optimize embryo quality.

Key facts

Study ID

NCT02418533

Run by

Main Line Fertility Center

People needed

109

Starts

2015-03-01

Expected to finish

2017-07-01

Last updated by the study team

2020-08-12

Who can join

Age: 21 and older, up to 38. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Patients undergoing IVF in an attempt to achieve pregnancy.
• Day 2-4 Follicle Stimulating Hormone (FSH) < 10 IU/ml, LH< 12 IU/ml, and estradiol <50 pg/ml on day 2-4 of menstrual cycle
• Antimullerian Hormone > 1.5
• Between 10 and 20 basal antral follicles on day 2-4 of the menstrual cycle
• Body weight >50 kg, with BMI > 18 and < 32 kg/m2

You may not qualify if…

• Smokers
• Polycystic ovarian disease
• Endometriosis greater than Stage I
• Testicular aspirated sperm
• Preimplantation Genetic Diagnosis (PGD) for single gene disorder
• Preimplantation Genetic Screening (PGS) banking cycles
• Donor Egg Cycles

Where it is running

• Main Line Fertility Center — Bryn Mawr, Pennsylvania, United States

Full record on ClinicalTrials.gov

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