Ketamine Infusion for Acute Sickle Cell Crisis in the Emergency Department

Stopped early · Not applicable

Conditions studied: Pain, Sickle Cell Disorder

In brief

Pain associated with sickle cell disease is a common emergency department visit. It is also frequently associated with a high emergency department recidivism rate for pain control and admissions to the hospital. Opiates are considered the first line therapy for acute flares and to manage chronic pain. This often times leads to a stigma of being "opiate seekers" or "frequent fliers". With this study, we wish to explore whether adding ketamine to standard acute opiate therapy (morphine or dilaudid) will decrease subsequent repeat doses of opiates while improving the patient's perception of pain. In addition, we will be exploring whether ketamine as an adjuvant therapy can help reduce hospital admissions for the management of acute sickle cell crisis pain.

Key facts

Study ID

NCT02417298

Run by

Billy Sin

People needed

12

Starts

2015-11-01

Expected to finish

2018-05-01

Last updated by the study team

2018-05-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients 18 years old and older presenting with acute sickle cell crisis pain either described as diffuse throughout the body or localized to joint/extremity/back
• Describes pain to be greater than or equal to 2 on the NRS
• Consents to IV access
• Provides informed consent

You may not qualify if…

• Receiving IM therapy only
• Standard therapy plan is not morphine or dilaudid
• Previous enrollment in study
• Documented fever or subjectively reported fever
• Complaint of chest pain or shortness of breath or abdominal pain or headache
• Suspicion for acute chest crisis
• Patients with history or acute diagnosis of subarachnoid hemorrhage/increased intracranial pressure
• Severe hypertension(≥180/100)
• History of CAD or hypertension
• Presence of/suspected for traumatic head injury with or without loss of consciousness
• Presence of/suspected for myocardial ischemia
• Presence of/suspected for alcohol intoxication
• Hemodynamic instability
• History of psychiatric disorders,
• Known or suspected pregnancy or breastfeeding
• Allergy to ketamine
• Administration of opioids in previous 4 hours
• Patients with language barriers
• Ilicit drug use within the past 7 days

Where it is running

• The Brooklyn Hospital Center — Brooklyn, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.