Postoperative Respiratory Monitoring After Neuraxial Opioid Administration for Cesarean Delivery
Completed
Conditions studied: Respiratory Depression
In brief
Respiratory depression occurs in labor and delivery; noticeably when neuraxial opioids are given.Pathophysiological respiratory depression -failure to respond to hypercapnia or hypoxia - is challenging to measure clinically.American Society of Anesthesiologist guidelines recommend suitable respiratory monitoring for 24 hours post cesarean delivery (CD). Use of capnograph will enable us to assess breath-by-breathe respiration in a population receiving neuraxial opioids - potentially at risk for respiratory depression. Our aim is to assess our ability to capture maternal postpartum respiratory parameters in a cohort following opioid neuraxial administration for CD.
Key facts
- Study ID
- NCT02417038
- Run by
- Stanford University
- People needed
- 80
- Starts
- 2015-04-01
- Expected to finish
- 2016-04-15
- Last updated by the study team
- 2017-05-04
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- American Society of Anesthesiologists physical status class I or II
- Age between 18 and 45
- Gestational age greater than 37 completed weeks
- Singleton pregnancy.
You may not qualify if…
- Contraindication for neuraxial analgesia (bleeding diathesis, neuropathy, severe scoliosis, previous spine surgery, local anesthetic allergy)
- Allergies to postoperative medication (opioids, NSAIDs, acetaminophen)
- Chronic opioid use
- Opioid administration in the previous 12 hours
- Inability to adequately understand the consent form
- Blocked nose or nasal deformity.
Where it is running
- Lucile Packard Children's Hospital — Palo Alto, California, United States
Full record on ClinicalTrials.gov
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