Brain Connectivity Supporting Language Recovery in Aphasia

Completed

Conditions studied: Aphasia, Stroke, Speech Disorders, Communications Disorders

In brief

The integrity of structural connectivity supporting cortical regions in the left brain hemisphere is hypothesized to enable treatment-induced naming recovery in persons with language difficulties after a stroke (aphasia). The investigators will map whole brain connectivity (i.e., the brain connectome) to investigate the role of cortical connectivity in impairment (Aim 1) and recovery (Aim 2) in patients with aphasia undergoing treatment. This information will be used to construct personalized markers of anomia treatment outcome (Aim 3), which may serve as a guide for speech-language pathologists and neurologists when facing patient management decisions.

Key facts

Study ID

NCT02416856

Run by

Medical University of South Carolina

People needed

74

Starts

2014-06-01

Expected to finish

2017-05-01

Last updated by the study team

2018-05-14

Who can join

Age: 25 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must be willing and able to give informed consent.
• Patients must be willing and able to comply with study requirements.
• Patients must be between 25- and 80-years of age.
• Patients must be native English speakers.
• Patients must be pre-morbidly right-handed.
• Patients must have sustained a one-time ischemic stroke in the left-hemisphere.
• Patients must be greater than 6-months post-stroke.
• Patients must have an aphasia diagnosis as confirmed by the Western Aphasia Battery-Revised.
• Patients must be MRI-compatible (e.g., no metal implants, not claustrophobic, etc.).
• Patients must achieve at least 65% accuracy on naming task during screening -

You may not qualify if…

• History of brain surgery
• Seizures during the previous 12 months
• Sensitive scalp (per patient report)
• Able to overtly name more than an average of 140 out of 175 items during the pre-treatment picture naming test (Philadelphia Naming Test) during Visits 2 or 3.
• Unable to overtly name at least an average of 5 out of 80 items during the pre-treatment fMRI sessions during Visits 2 or 3.

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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