Metabolic Effects of Non-nutritive Sweeteners

Completed · Not applicable

Conditions studied: Obesity

In brief

The purpose of this research study is to examine whether sugar-replacement sweeteners that are currently on the market (ex. Sucralose, which is in Splenda) change how well the body works to control blood sugar.

Key facts

Study ID

NCT02413424

Run by

University of Illinois at Urbana-Champaign

People needed

38

Starts

2015-04-01

Expected to finish

2017-07-01

Last updated by the study team

2017-09-21

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI ≥ 30 kg/m2 or BMI ≥ 18 kg/m2 and BMI<25 kg/m2
• "insulin sensitive": based on the homeostasis model assessment of insulin resistance (HOMA-IR) <3

You may not qualify if…

• BMI ≥ 25 kg/m2 and BMI<30 kg/m2
• HOMA-IR>3
• Current smoker or quit smoking less than 6 months ago
• pregnancy or breastfeeding
• subjects who have malabsorptive syndromes, phenylketonuria, inflammatory intestinal disease, liver or kidney diseases, diabetes
• subjects who are taking any medication that might affect metabolism
• anemia
• regular use of non-nutritive sweeteners

Where it is running

• University of Illinois at Urbana Champaign — Urbana, Illinois, United States

Full record on ClinicalTrials.gov

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