Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension

Completed · Not applicable

Conditions studied: Essential Hypertension

In brief

Children are increasingly being diagnosed with essential hypertension and the absence of comparative effectiveness research in antihypertensive therapies has contributed to considerable differences in prescribing practices among physicians treating children with essential hypertension. This study will consist of a series of systematically-administered n-of-1 trials among children to verify the need for ongoing antihypertensive treatment and if so, to identify the preferred single drug therapy.

Key facts

Study ID

NCT02412761

Run by

The University of Texas Health Science Center, Houston

People needed

42

Starts

2013-06-01

Expected to finish

2016-07-01

Last updated by the study team

2018-11-15

Who can join

Age: 9 and older, up to 22. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of essential hypertension
• Treating physician has determined that pharmacologic therapy is necessary

You may not qualify if…

• Compelling indication to select one particular medication
• Specific contraindication for any of the 3 therapies

Where it is running

• University of Texas at Houston Medical School; Pediatric Nephrology and Hypertension Clinics — Houston, Texas, United States

Full record on ClinicalTrials.gov

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