Sympatholysis in Chronic Kidney Disease

Recruiting now · Phase 1 · Has a placebo group

Conditions studied: Chronic Kidney Disease

In brief

The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).

Key facts

Study ID

NCT02411773

Run by

Emory University

People needed

110

Starts

2015-06-11

Expected to finish

2027-06-01

Last updated by the study team

2026-05-18

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Veterans with Stages III and IV Chronic Kidney Disease (CKD)
• Kidney transplant recipients with varying degrees of kidney function
• Veterans 18-75 years old, without kidney disease, as study controls
• Exercise less than 20 minutes twice per week
• Willing and able to cooperate with the protocol

You may not qualify if…

• Severe CKD (estimated glomerular filtration rate (eGFR) < 15 cc/minute)
• Metabolic alkalosis (serum bicarbonate > 28 meq/L)
• Ongoing drug or alcohol abuse
• Diabetic neuropathy
• Any serious systemic disease that might influence survival
• Severe anemia with hemoglobin (Hbg) level < 10 g/dL
• Clinical evidence of congestive heart failure or ejection fraction below 35%
• Symptomatic heart disease determined by prior electrocardiogram, stress test, and/or history
• Treatment with central alpha agonists (clonidine)
• Uncontrolled hypertension with blood pressure (BP) greater than 170/100 mmHg
• Low blood pressure with BP less than 100/50 mmHg
• Pregnancy or plans to become pregnant
• Current treatment with monoamine oxidase inhibitors (MAOIs)
• Inability to exercise on a stationary bicycle

Where it is running

• Atlanta VA Medical Center — Decatur, Georgia, United States (enrolling)

Full record on ClinicalTrials.gov

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