Dexamethasone for Treatment of Radiation-related Fatigue in Patients Receiving RT for Head-neck and Lung Cancer

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Head and Neck Cancer, Non-small Cell Lung Cancer

In brief

This study will look at how dexamethasone and placebo influence radiation fatigue, quality of life and number of treatment days missed during radiation therapy or radiation therapy and chemotherapy for cancer.

Key facts

Study ID: NCT02410382
Run by: University of Arizona
People needed: 79
Starts: 2014-08-27
Expected to finish: 2018-02-16
Last updated by the study team: 2019-05-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

confirmation of head \& neck cancer (stage I-IV) or non-small cell lung cancer (stage II \& III)
Undergoing treatment with either radiation alone or in combination with chemotherapy
Normal cognition and willingness to complete fatigue and quality of life forms, patient observation form, and pill diary

You may not qualify if…

Hypersensitivity to dexamethasone or corticosteroids or Equal sugar substitute
Corticosteroid within the past 30 days prior to study enrollment for greater than one week duration
Planned Stereotactic Body Radiation Therapy (SBRT)
Active psychosis
Current pregnancy
Active peptic ulcer disease or evidence of gastrointestinal bleed
Current active tuberculosis or systemic fungal infection
Previous diagnosis of diabetes mellitus
Acute febrile illness
Known human immunodeficiency virus or acquired immunodeficiency syndrome
Major surgery within two weeks of study enrollment of which the patient has not recovered
Psychostimulant use in the past 30 days prior to registration
History of phenylketonuria (PKU)

Where it is running

University of Arizona — Tucson, Arizona, United States

Full record on ClinicalTrials.gov

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