Pilot Project to Examine the Effects of Exercise on Nocturnal Lipolysis in Men and Women

Completed

Conditions studied: Healthy

In brief

The goal of this proof of concept/feasibility study is to use rigorous methodology to explore links between daytime energy status and nocturnal fat metabolism in healthy adults.

Key facts

Study ID

NCT02408510

Run by

University of Colorado, Denver

People needed

15

Starts

2015-08-01

Expected to finish

2017-09-01

Last updated by the study team

2019-07-01

Who can join

Age: 20 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males and Females, 20-35 years of age
• Sedentary (planned exercise < 3 d/week, < 30 min/session)
• Lifetime maximum BMI of 30 kg/m2
• Weight stable by self-report for at least 2 mo before the study (<5% weight change)
• Habitual sleeping pattern of >7 hours not to exceed 9.25 hours of sleep per night
• Zero to low-moderate caffeine intake (not to exceed 500 mg/d)
• Alcohol use fewer than two standard drinks per day per week for males and one or less drinks per day per week for females.

You may not qualify if…

• Current smoker
• Use of any medication that could affect lipid metabolism, insulin signaling, or sleep
• Pregnant women will not be enrolled in the study
• Current or chronic medical/psychiatric conditions
• Shift work or dwelling below Denver altitude (1,600 m) a year prior to testing
• Travel across more than one time zone 3 wk before study
• Abnormal eating patterns identified by interview and eating questionnaire
• Screening positive for illicit drugs
• Chronic health conditions such as diabetes,
• Hyper or hypothyroidism
• Sleep apnea (Apnea-Hypopnea Index >5)
• Renal or liver disease, anemia, or cancer
• Regularly go to sleep after midnight
• One or more of the following out-of-range values measured on a fasting blood sample:
• glucose > 110 mg/dl,
• thyroid stimulating hormone <0.5 or >5.0 uU/ml,
• hemoglobin < 14.5 g/dl men, <12.3 g/dl women,
• alanine amino transferase > 47 U/l,
• aspartate aminotransferase > 47 U/l,
• alkaline phosphatase <39 or >117 U/l, or
• creatinine >1.1 mg/dl.

Where it is running

• University of Colorado Hospital — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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