Cough in Reduced True Vocal Fold Mobility
Completed
Conditions studied: Unilateral Vocal Cord Paresis, Unilateral Vocal Cord Paralysis
In brief
This project is a first attempt to assess cough airflow dynamics and true vocal fold (TVF) adduction and abduction angles during voluntary cough to examine the effects of changes in glottal closure due to reduced mobility of one true vocal fold. The hypothesis of this study is that the incomplete glottal closure due to reduced vocal fold mobility will result in changes in true vocal fold adductory and abductory angles during cough and will result in changes to voluntary cough airflow parameters. This study results will contribute to the existing knowledge of the laryngeal contribution to cough airflow dynamics.
Key facts
- Study ID
- NCT02407301
- Run by
- University of Florida
- People needed
- 15
- Starts
- 2015-04-01
- Expected to finish
- 2016-02-01
- Last updated by the study team
- 2016-05-13
Who can join
Age: 40 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age between 40 and 75 years.
- Glottal insufficiency secondary to reduced TVF mobility confirmed with the endoscopic evaluation performed by an otolaryngologist.
- The ability to provide informed consent.
- No history of chronic obstructive pulmonary disease, lung cancer, and/or lung transplant.
- No history of neurodegenerative disease such as Parkinson's disease, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or progressive supranuclear palsy (PSP), Alzheimer's disease, or dementia.
You may not qualify if…
- Chest infection within one month prior to the study participation.
- History of the adverse reaction associated with laryngoscopy.
Where it is running
- University of Florida ENT Clinic — Gainesville, Florida, United States
- University of Florida Speech and Hearing Center — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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