Effect of Over-the-counter Dietary Supplements on Kidney Stone Risk

Completed · Not applicable

Conditions studied: Hyperoxaluria

In brief

The purpose of this study is to ascertain whether certain supplements promote excessive urinary oxalate excretion and increase the risk for calcium oxalate kidney stones. Supplements that enhance urinary oxalate excretion, as a result of their oxalate concentration or from some other mechanism (e.g., providing substrate for oxalate biosynthesis) will be identified by the investigators.

Key facts

Study ID

NCT02404701

Run by

University of Wisconsin, Madison

People needed

45

Starts

2015-02-01

Expected to finish

2016-10-01

Last updated by the study team

2016-10-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• At least 18 years of age, no prior personal history of kidney stones

You may not qualify if…

• Personal history of kidney stones (by subjects' report); known allergy to any of the dietary supplements to be used in the study (by subjects' report); short bowel; active ulcerative colitis or irritable bowel disease; Crohns or Celiac disease; renal tubular acidosis; current use of topiramate or other carbonic anhydrase inhibitor, steroids, allopurinol, thiazide diuretics, or supplemental ascorbic acid >250 mg/day.

Where it is running

• Department of Urology, School of Medicine & Public Health, University of Wisconsin — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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