Pericardial Fat and Inflammation in HIV Patients and Controls

Completed

Conditions studied: Coronary Artery Disease, Human Immunodeficiency Virus (HIV)

In brief

The investigators propose to correlate 1) cardiac MRI pericardial adipose volume, 2) the presence of pericardial monocytes and 3) circulating immune biomarkers in persons with and without CHD and HIV infection compared to seronegative controls with known CHD. The investigators aim to test the hypothesis that higher amounts of pericardial fat deposition and increased presence of monocytes within this adipose tissue are associated with underlying coronary artery disease in persons with HIV infection as measured by cardiac MRI.

Key facts

Study ID

NCT02399384

Run by

University of Cincinnati

People needed

12

Starts

2015-01-14

Expected to finish

2018-07-01

Last updated by the study team

2020-01-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• > 18 years of age
• History of HIV disease or no history of HIV
• Prior history of left heart catheterization or CTA indicating the presence or absence of CAD.

You may not qualify if…

• Unable to have a contrast enhanced cardiac MRI, (i.e. ferromagnetic foreign body, inability to follow verbal instructions, prior history of allergic reactions to gadolinium, history of nephrogenic systemic fibrosis, severe renal dysfunction GFR<30 ml/min/1.73 m2, or severe claustrophobia/anxiety);
• Chronic kidney disease patient undergoing hemodialysis or peritoneal dialysis
• Allergy to Iron Compounds;
• Pregnant females.

Where it is running

• University of Cincinnati Medical Center — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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