A Phase 2 Study of MM-141 Plus Nab-paclitaxel and Gemcitabine in Front-line Metastatic Pancreatic Cancer

Completed · Phase 2 · Has a placebo group

Conditions studied: Pancreatic Cancer

In brief

The purpose of this study is to determine whether the combination of MM-141 plus nab-paclitaxel and gemcitabine is more effective than nab-paclitaxel and gemcitabine alone based on Progression Free Survival (PFS) in front-line metastatic pancreatic cancer patients with high serum levels of free IGF-1.

Key facts

Study ID

NCT02399137

Run by

Merrimack Pharmaceuticals

People needed

88

Starts

2015-05-01

Expected to finish

2018-08-01

Last updated by the study team

2018-09-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Metastatic adenocarcinoma of the pancreas. Patients with islet cell neoplasms are not eligible.
• Patient must have received no prior radiotherapy, surgery, chemotherapy, or investigational therapy for the treatment of metastatic disease.
• Blood sample sent for free IGF-1 testing
• ECOG performance status (PS) of 0 or 1

You may not qualify if…

• Patients who only present with localized disease
• Patients with CNS malignancies (primary or metastatic)
• Clinically significant cardiac disease

Where it is running

• Pacific Cancer Medical Center, Inc. — Anaheim, California, United States
• St. Jude Heritage Healthcare — Fullerton, California, United States
• UCLA School of Medicine — Los Angeles, California, United States
• Cancer Care Assoc Med Grp — Redondo Beach, California, United States
• UCSF Cancer Center — San Francisco, California, United States
• Sansum Clinic — Santa Barbara, California, United States
• Central Coast Med Onc Corp — Santa Maria, California, United States
• Rocky Mountain Cancer Centers — Aurora, Colorado, United States
• Baptist Health Med Gr Onc, LLC — Miami, Florida, United States
• Florida Cancer AffiliatesOcala — Ocala, Florida, United States
• Memorial Regional Hospital — Pembroke Pines, Florida, United States
• Cancer Treatment Centers of America-Georgia — Newnan, Georgia, United States
• Northwestern University — Chicago, Illinois, United States
• University of Illinois at Chicago — Chicago, Illinois, United States
• Illinois Cancer Specialists — Chicago, Illinois, United States
• Oncology Specialists, S.C. — Park Ridge, Illinois, United States
• Midwest Regional Medical Cntr — Zion, Illinois, United States
• Nylen Cancer Center — Sioux City, Iowa, United States
• Cancer Center of Acadiana Research Department — Lafayette, Louisiana, United States
• Reliant Medical Group, Inc. — Worcester, Massachusetts, United States
• Compr Cancer Centers of Nevada — Henderson, Nevada, United States
• New York Oncology HematologyPC — Albany, New York, United States
• Roswell Park Cancer Inst — Buffalo, New York, United States
• Bassett Cancer Institute — Cooperstown, New York, United States
• Banner MD Anderson Cancer Ctr. — Gilbert, Arizona, United States

Full record on ClinicalTrials.gov

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