Role of Glucagon In Glucose Control in Cystic Fibrosis Related Diabetes
Completed · Early Phase 1
Conditions studied: Cystic Fibrosis, Cystic Fibrosis Related Diabetes
In brief
This project is designed to begin to characterize the abnormalities of glucagon secretion in subjects with cystic fibrosis related diabetes along the spectrum of glucose tolerance. Cystic fibrosis patients with normal glucose tolerance as well as cystic fibrosis related diabetes as well as control subjects will undergo an oral glucose tolerance test, mixed meal tolerance test, and one step hypoglycemic clamp. Cystic fibrosis patients will then return 12 months later to undergo repeat mixed meal tolerance test and hypoglycemic clamp test.
Key facts
- Study ID
- NCT02398383
- Run by
- Yale University
- People needed
- 7
- Starts
- 2015-03-01
- Expected to finish
- 2017-06-22
- Last updated by the study team
- 2020-06-26
Who can join
Age: 12 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Diagnosis of CF by clinical or genetic determination
- Normal glucose tolerance or CFRD
- Subjects routinely taking systemic or inhaled glucocorticoids on stable regimen are eligible
You may not qualify if…
- Subjects with active pulmonary infection requiring supplemental doses of corticosteroids
- Use of any oral diabetes medications
- Subjects who are pregnant/lactating
- Subjects with poor compliance with pancreatic enzyme replacement therapy
- Control Subjects:
- Approximately 10 control subjects who are matched for age, gender, are expected to be enrolled in the study. Non-CF subjects must be >12 years old, in good health and not taking any medications or have any medical problems the doctor feels would prevent the subject from completing the study and have BMI between 15-85% for age and gender. Control subjects whose fasting blood glucose is found to be >110 mg/dL will not be continued in the study.
Where it is running
- Yale New Haven Hospital — New Haven, Connecticut, United States
Full record on ClinicalTrials.gov
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