Contrast Ultrasound Perfusion Imaging in PAD With Sonazoid

Status unconfirmed · Phase 2

Conditions studied: Peripheral Artery Disease

In brief

The measurement of limb skeletal muscle perfusion and perfusion reserve during exercise is an approach that can assess the total impact of the complex pathophysiologic processes in patients with limb ischemia, particularly in those with diabetes in whom distal arterial disease and abnormal microvascular functional responses are common. This trial is designed to: (a) optimize methods for assessment of limb perfusion at rest and during stress using contrast-enhanced ultrasound (normal subjects) and a microbubble contrast agent that is able to provide non-linear signal without destruction at medium acoustic pressures, and (b) to test whether perfusion imaging provides incremental information on the severity of disease in patients with peripheral artery disease.

Key facts

Study ID

NCT02398266

Run by

Oregon Health and Science University

People needed

55

Starts

2016-08-01

Expected to finish

2018-07-01

Last updated by the study team

2017-06-19

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• For Healthy controls: no active major medical problems or vasoactive medications
• For PAD: Known diagnosis with PAD an ABI of 0.4-0.6

You may not qualify if…

• Rutherford class 6 or greater
• Allergy to ultrasound contrast agents
• Previous limb amputation
• Pregnancy
• Known congenital or acquired right to left shunt

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States (enrolling)

Full record on ClinicalTrials.gov

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