Modulation Of Airway Reactivity With Chronic Mechanical Strain

Completed · Not applicable · Has a placebo group

Conditions studied: Asthma

In brief

The purpose of this study is to see if the use of a machine called CPAP will help children with asthma breathe better. CPAP is a machine that produces airflow to help people with breathing problems. To use it, you will wear a mask connected by a hose to the CPAP machine. We believe that use of CPAP may be a treatment for children with asthma.

Key facts

Study ID

NCT02396849

Run by

Indiana University

People needed

84

Starts

2015-01-01

Expected to finish

2020-01-09

Last updated by the study team

2021-03-09

Who can join

Age: 8 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children 8-17 yrs olds with severe asthma (N=120) will be recruited from the Pediatric High Risk Asthma Clinic and Pulmonary Clinics at Riley Hospital for Children at Indiana University Health.
• Severe asthma will be defined by the need for medication therapies following steps 4-6 according to the National Institutes of Health's Asthma Care Quick Reference, September 2012 or high dose of inhaled corticosteroids
• On a stable regimen of asthma medications for at least 8 weeks prior to enrollment without systemic corticosteroids for ≥ 4 weeks

You may not qualify if…

• Obese (>95% predicted BMI)
• Congenital heart disease or chronic lung disease
• History of pneumothorax
• Inability to perform pulmonary function testing
• Oxygen saturation <93%
• forced expiratory volume at one second (FEV1) <70% predicted
• Provocative concentration causing a 20% drop in FEV1 from baseline (PC20) ≥16 mg/ml of methacholine.

Where it is running

• Riley Hospital for Children — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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