The Longitudinal Ovarian Reserve Study
Completed
Conditions studied: Effects of Chemotherapy
In brief
Postmenarchal female cancer patients scheduled to undergo cancer therapy may enroll in this study to assess changes in existing and novel surrogate measures of fertility potential before, during and after chemotherapy. Measures of fertility potential to be tested include ultrasound imaging for antral follicle counts and ovarian volumes, endocrine evaluation, and assessment of oxidative stress.
Key facts
- Study ID
- NCT02395341
- Run by
- University of Pennsylvania
- People needed
- 20
- Starts
- 2007-05-01
- Expected to finish
- 2013-04-01
- Last updated by the study team
- 2016-08-22
Who can join
Age: 15 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Females with the diagnosis of cancer schedules to be treated with chemotherapy and or radiation therapy.
- Age between 15-45 years.
- Post-menarchal.
- Presence of a uterus and both ovaries.
- Ability and willingness to comply with study protocol.
- Have given written informed concent (or assent with parental consent in minors), prior to any study-related procedure, not part of normal medical care, with the understanding that consent may be withdrawn byt he patient at any time without prejudice to their future medical care.
You may not qualify if…
- Current pregnancy.
- Lactation within the previous 3 months.
- Any medical condition other than cancer, with in the judgment of the investigator is known to be associated with premature ovarian failure (such as Turner's Syndrome or Fragile X) or ovulatory dysfunction (such as thyroid disease, adrenal dysfunction, Cushing's syndrome, hyperprolactinemia, and polycystic ovarian syndrome).
Where it is running
- Penn Reproductive Research Unit, 3701 Market Street, Suite 810 — Philadelphia, Pennsylvania, United States
- Penn Medicine at Radnor, 250 King of Prussia Road — Radnor, Pennsylvania, United States
Full record on ClinicalTrials.gov
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