Cough According to Stimulus Type in PD

Completed · Phase 1

Conditions studied: Parkinson's Disease

In brief

Aspiration pneumonia (APn) occurs at a higher rate in patients with Parkinson's disease (PD) versus healthy adults. This is of particular public health concern given that death secondary to aspiration pneumonia and lung infection is a leading cause of death in persons with PD. Swallowing and cough function are affected in PD, putting people with PD at significant risk for uncompensated aspiration (aspiration without adequate cough response). One challenge in the management of airway protective deficits related to PD is the chronic and progressive nature of the disease, where swallowing dysfunction appears subtly in the form of microaspiration, reducing the perceived urgency of the swallowing disorder by both clinicians and patients. The long-term goal of this research is to advance the management of airway protection deficits in patients with neurodegenerative disease in order to decrease morbidity and mortality due to aspiration related lung infection. The objective here is to further specify deficits leading to uncompensated airway compromise in PD in order to advance the clinical management of these patients, leading to an immediate positive impact.

Key facts

Study ID

NCT02390089

Run by

University of Florida

People needed

158

Starts

2015-04-01

Expected to finish

2019-02-13

Last updated by the study team

2019-02-15

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Within age limits
• For PD group: confirmed diagnosis of idiopathic parkinson's disease

You may not qualify if…

• Uncontrolled hypertension
• Difficulty complying due to neuropsychological dysfunction (i.e., severe depression)
• Allergy to capsaicin or hot peppers
• History of head or neck cancer
• Neurological disorders other than PD (i.e., stroke, etc.)
• control participants only: any history of neurologic disorders including PD
• History of smoking in the last 5 years
• Breathing disorders or diseases

Where it is running

• University of Florida Center for Movement Disorders and Neurorestoration — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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