Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine

Completed · Phase 4

Conditions studied: Migraine

In brief

Opioids are commonly used to treat migraine in North American Emergency Departments. We are comparing efficacy and adverse events of hydromorphone, an opioid, to that of prochlorperazine, a dopamine antagonist with known efficacy in migraine. Prochlorperazine will be combined with diphenhydramine to prevent adverse events.

Key facts

Study ID

NCT02389829

Run by

Montefiore Medical Center

People needed

127

Starts

2015-03-01

Expected to finish

2016-10-01

Last updated by the study team

2018-08-31

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Migraine headache (International Classification of Headache Disorders 3B criteria)

You may not qualify if…

• Brain imaging ordered
• Fever
• Objective neurological findings
• Pregnancy/ breast feeding
• Allergy/ contraindication to investigational medication
• History of addiction to opioids, use of methadone, any use of opioids previous 30 days

Where it is running

• Montefiore Medical Center--Einstein — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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