A Study of Varlilumab (Anti-CD27) and Sunitinib in Patients With Metastatic Clear Cell Renal Cell Carcinoma

Stopped early · Phase 1

Conditions studied: Carcinoma, Renal Cell, Kidney Diseases, Kidney Neoplasms, Urogenital Neoplasms, Urologic Diseases, Urologic Neoplasms, Neoplasms, Neoplasms by Histologic Type, Clear-cell Metastatic Renal Cell Carcinoma

In brief

This is a study to determine the clinical benefit (how well the drug works), safety, and tolerability of combining varlilumab and sunitinib. The study will enroll patients with metastatic clear cell renal cell carcinoma.

Key facts

Study ID

NCT02386111

Run by

Celldex Therapeutics

People needed

17

Starts

2015-05-01

Expected to finish

2017-11-03

Last updated by the study team

2018-07-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed diagnosis of predominant clear cell renal cell carcinoma.
• Advanced metastatic disease
• Documented progressive disease based on radiographic, clinical or pathologic assessment during or subsequent to last therapy.
• For Phase l, no more than 3 prior anticancer regimens (IL-2 or interferon do not count towards the total).
• Measurable (target) disease.
• Life expectancy ≥ 12 weeks.
• If of childbearing potential (male or female), agrees to practice an effective form of contraception during study treatment and for at least 70 days following last treatment dose.
• Must have available tumor tissue and consent to biopsy while on study.

You may not qualify if…

• Prior therapy with an anti-CD27 antibody.
• Previous treatment with sunitinib.
• Use of any experimental immunotherapy.
• Chemotherapy within 21 days or at least 5 half-lives (whichever is shorter) prior to the planned start of study treatment.
• Systemic radiation therapy within 4 weeks, prior focal radiotherapy within 2 weeks, or radiopharmaceuticals (strontium, samarium) within 8 weeks prior to the first dose of study treatment.
• Use of immunosuppressive medications within 4 weeks or systemic corticosteroids within 2 weeks prior to first dose of study treatment.
• Other prior malignancy, except for adequately treated basal or squamous cell skin cancer or in situ cancers; or any other cancer from which the patient has been disease-free for at least 3 years.
• Active, untreated central nervous system metastases.
• Active autoimmune disease or a documented history of autoimmune disease.
• Active diverticulitis.
• Significant cardiovascular disease including CHF or poorly controlled hypertension.
• Impairment of gastrointestinal function or gastrointestinal disease that may alter the absorption of sunitinib.

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• UC Davis Comprehensive Cancer Center — Sacramento, California, United States
• UCSF Helen Diller Comprehensive Cancer Center — San Francisco, California, United States
• George Washington University-Medical Faculty Associates — Washington D.C., District of Columbia, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Barbara Ann Karmanos Cancer Institute — Detroit, Michigan, United States
• Nebraska Cancer Specialists — Omaha, Nebraska, United States
• Mount Sinai Medical Center — New York, New York, United States
• Thomas Jefferson University — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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