Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Active Cocaine Users

In brief

Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for treatment of cocaine abuse and dependence. This study will incorporate choice self-administration procedures between drug and a non-drug alternative reinforcer presented during maintenance on d-amphetamine, which has been previously shown to reduce cocaine use.

Key facts

Study ID

NCT02383043

Run by

Joshua A. Lile, Ph.D.

People needed

18

Starts

2015-02-01

Expected to finish

2018-04-05

Last updated by the study team

2019-04-11

Who can join

Age: 21 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Recent cocaine use, otherwise healthy

You may not qualify if…

• Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease

Where it is running

• Laboratory of Human Behavioral Pharmacology — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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