Glaucoma Management in the African-Derived Developing World Using Trabeculoplasty

Completed · Not applicable

Conditions studied: Glaucoma

In brief

This proposal aims to evaluate selective laser trabeculoplasty (SLT) as a safe and effective therapy to control open-angle glaucoma and reduce the risk of progression to visual dysfunction or blindness in the African-derived developing world. If funded, this work will complete the characterization of SLT's safety and efficacy profile as a means of long-term disease control in this population. This work will support the translation of SLT into a structured public health initiative to reduce glaucoma-related vision loss throughout the African-derived developing world.

Key facts

Study ID

NCT02375009

Run by

West Virginia University

People needed

129

Starts

2015-03-01

Expected to finish

2018-09-01

Last updated by the study team

2021-06-18

Who can join

Age: 30 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Afro-Caribbean ancestry
• Ages 30 and above
• Open-angle glaucoma (ISGEO criteria)
• CDR≥0.7 or CDR asymmetry ≥0.2 or rim width ≤0.1 CDR with typical VF loss; or
• CDR≥0.8 or CDR asymmetry ≥0.3 (if unable to get VF); or
• VA <20/400 and IOP ≥ 32 mmHg (if unable to get VF or CDR)
• Receiving ≤2 topical IOP-lowering medications
• IOP between 17-35 mmHg in both eyes after 30-day washout

You may not qualify if…

• Any glaucoma other than open-angle glaucoma
• Advanced glaucoma (CDR > 0.9 or field loss in central 10º)
• History of:
• Prior glaucoma laser or surgery
• Ocular inflammation within 3 months
• Ocular trauma or intraocular surgery within 6 months

Where it is running

• West Virginia University Eye Institute — Morgantown, West Virginia, United States

Full record on ClinicalTrials.gov

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