Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism

Completed · Not applicable

Conditions studied: Congenital Hypothyroidism

In brief

This is a clinical study comparing targeted levothyroxine dosing based on thyroid anatomy as visualized on ultrasound (normal vs. ectopic/sublingual vs. athyreosis) to empiric levothyroxine dosing in infants with congenital hypothyroidism. Patients enrolled in the study for targeted dosing will be compared to controls obtained by retrospective chart review. The main outcome is to determine if there is a difference in the frequency of over-treatment and under-treatment during the first 6 months of therapy.

Key facts

Study ID

NCT02374593

Run by

Erica Eugster

People needed

24

Starts

2014-03-01

Expected to finish

2016-05-01

Last updated by the study team

2017-10-09

Who can join

Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Newborns diagnosed with congenital hypothyroidism (CH).
• Newborns with CH who are treated by a pediatric endocrinologist at Riley Hospital for Children or satellite location.
• Newborns with CH who have thyroid imaging performed (thyroid ultrasound or technetium scan) at diagnosis.

You may not qualify if…

• Newborns who do not have CH.
• Newborns with CH who have not had thyroid imaging performed at diagnosis.

Where it is running

• Riley Hospital for Children — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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