Fatty Acid Regulation of Platelet Function in Diabetes

Completed

Conditions studied: Thrombosis, Type 2 Diabetes Mellitus

In brief

This study investigates the potential protective effects of altering fatty acid in the platelet as a method for prevention of platelet activation and thrombosis in type 2 diabetes mellitus. Fatty acids (omega-3 and omega-6) and their oxidized lipids will be evaluated for protection from agonist-mediated platelet activation in platelets from type 2 diabetics and healthy controls.

Key facts

Study ID

NCT02373332

Run by

University of Michigan

People needed

90

Starts

2013-08-01

Expected to finish

2019-05-21

Last updated by the study team

2021-06-03

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy subjects and T2DM patients
• African American and Caucasian
• T2DM patients on controlled medication (taking metformin)

You may not qualify if…

• Dietary supplement within 2 weeks of enrollment
• Fish and plant oil supplements 2 months prior to enrollment
• NSAIDS and aspirin 1 week prior to enrollment
• Smoking
• Cardiovascular event within 6 months prior to enrollment
• Other anti-platelet treatment including phosphodiesterase (PDE) and P2Y12R inhibitors
• Estimated Glomerular Filtration Rate (eGFR) below 30 (severe renal insufficiency)
• eGFR above 90

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States
• Thomas Jefferson University — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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