Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects

Completed

Conditions studied: Familial Frontotemporal Dementia

In brief

This study is being done to learn more about normal thinking and behavior, mild thinking and behavior problems, Frontotemporal Dementia and other forms of dementia in families in which one or more relatives have a mutation associated with Frontotemporal Dementia.

Key facts

Study ID

NCT02372773

Run by

Mayo Clinic

People needed

398

Starts

2015-04-01

Expected to finish

2020-06-30

Last updated by the study team

2020-08-03

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Must be a member of family with a known mutation in one of the three major FTLD related genes: MAPT, PGRN, or C9ORF72.
• At least 18 years of age.
• The predominant phenotype in the kindred must be cognitive/behavioral (ie, kindreds in whom parkinsonism or ALS is the predominant clinical phenotype among affected relatives may be excluded)
• Have a reliable informant who personally speaks with or sees that subject at least weekly.
• Subject is sufficiently fluent in English to complete all measures
• Subject must be willing and able to consent to the protocol and undergo yearly evaluations over 3 years.
• Subject must be willing and able to undergo neuropsychological testing (at least at baseline visit).
• Subject must have no contraindication to MRI imaging.

You may not qualify if…

• Known presence of a structural brain lesion (e.g. tumor, cortical infarct).
• Presence of another neurologic disorder which could impact findings (eg, multiple sclerosis).
• Subject is unwilling to return for follow-up yearly, undergo neuropsychological testing and MR imaging.
• Subject has no reliable informant.

Where it is running

• University of California, San Francisco, Memory and Aging Center, Department of Neurology — San Francisco, California, United States
• Mayo Clinic Florida — Jacksonville, Florida, United States
• Harvard University — Charlestown, Massachusetts, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Washington University — St Louis, Missouri, United States
• Columbia University — New York, New York, United States
• Univerisity of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of British Columbia — Vancouver, British Columbia, Canada

Full record on ClinicalTrials.gov

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