Genetics of Hyperuricemia Therapy in Hmong

Completed

Conditions studied: Hyperuricemia, Gout

In brief

To pursue this objective, we will be measuring uric acid at baseline and post 14 days of twice daily allopurinol therapy in 30 Hmong participants with documented gout or hyperuricemia and known genotype for key renal transporters of uric acid.

Key facts

Study ID

NCT02371421

Run by

University of Minnesota

People needed

80

Starts

2014-06-01

Expected to finish

2016-12-01

Last updated by the study team

2019-07-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Both parents are Hmong (self report)
• Self report history of gout, or
• History (within one year) of active use of xanthine oxidase inhibitors, or
• Evidence of serum uric acid ≥ 6mg/dL , or
• Serum uric acid < 6mg/dL with history of ≥ 2 gout episodes within the last 6 months
• Ability to provide informed consent for participation in the study
• Demonstrate understanding of the study procedures and ability to comply with the study drug for the entire length of the study
• Ability to obtain permission from treating clinician to allow stopping the drug for 10 days

You may not qualify if…

• Pregnant women or women of childbearing age sexually active and not using any contraception
• estimated creatinine clearance (eCrCl) <30ml/min
• Elevated liver enzymes (3 x upper normal limit of liver function tests (AST and ALT))
• Contraindication to receiving allopurinol
• Active participation in other clinical trial (or within 30 days)

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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