Utility of Thenar Near Infrared Spectroscopy (NIRS) in Pediatric Patients With Heart Failure
Recruiting now
Conditions studied: Heart Failure
In brief
This is a single-center, non-randomized study.The study staff will use the InSpectraTM tissue oxygen saturation (StO2) monitor manufactured by Hutchinson Technology to measure baseline StO2 levels after applying the noninvasive probe to the thenar eminence. After a stable reading is obtained, a blood pressure cuff will be inflated 40 mmHg above the obtained systolic pressure and the rate of desaturation (Rdes; % × sec-1) will be recorded. After 3 minutes or once the StO2 level comes to zero (whichever is earlier), the cuff pressure will be released and the rate of reperfusion (Rres; % × sec-1) will be measured. The investigators hypothesize that heart failure in children causes a baseline lower thenar tissue oxygen saturation (StO2), a faster rate of desaturation (Rdes) and a prolonged rate of reperfusion (Rres). The investigators also hypothesize that these changes will correlate with the severity of heart failure. The results of this study will provide groundwork for studies looking at correlation of therapy modification based on the combination thenar StO2 and clinical presentation.
Key facts
- Study ID
- NCT02368041
- Run by
- University of Florida
- People needed
- 130
- Starts
- 2015-05-01
- Expected to finish
- 2027-05-10
- Last updated by the study team
- 2026-03-12
Who can join
Age: any, up to 25. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Heart failure patients under 25 years of age with a diagnosis of cardiomyopathy, myocarditis or univentricular palliation for congenital heart disease who are stable on their medical management will be enrolled.
You may not qualify if…
- Patients presenting with acute deterioration in clinical status
- Patients with active infection
- Patients with autoimmune vasculitis disorder
- Patients with limb deformities and painful disorders of extremities
- Patients with underlying bone disorders, (e.g. osteogenesis imperfecta)
- Patients with severe anemia (Hb <7g/dL)
- Patients with peripheral vascular disease which can alter the microcirculation
Where it is running
- University of Florida — Gainesville, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
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