Neovascular Morphology and Persistent Disease Activity Among Patients With NV AMD

Completed

Conditions studied: Neovascular Age-Related Macular Degeneration

In brief

Neovascular Age-Related Macular Degeneration (NV AMD) remains the leading cause of vision loss among people over 65. Intravitreal injections with drugs that block VEGF have revolutionized treatment of NV AMD. However, less than 40% of treated patients have clinically significant imporovement in vision. In this study, we will determine the relative frequency of neovascular subtypes in two groups: 1) a representative, treatment-naive NV AMD patient population, and 2) a population of patients who develop recurrent NV AMD activity while off treatment and assess the frequency of persistent disease activity (PDA) according to specific neovascular morphologic subtypes. This information will clarify the scope of the PDA problem and will identify patients with PDA who may benefit from additional therpeutic strategies.

Key facts

Study ID

NCT02367365

Run by

Duke University

People needed

75

Starts

2014-12-01

Expected to finish

2017-12-01

Last updated by the study team

2018-02-12

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of either treatment naive NVAMD or newly reactivated NVAMD which has been previously quiescent off treatment
• Men and women aged 50 years or older
• Able to provide written informed consent

You may not qualify if…

• Potential study eye with ongoing (within previous 6 months of diagnosis of NVAMD disease activity) treatment for CNV, including anti-VEGF medications, corticosteroids, photodynamic therapy, thermal laser photocoagulation, transpupillary thermotherapy, or pneumatic displacement of macular hemorrhage
• CNV secondary to causes other than AMD
• Known or suspected sensitivity or allergy to ICG dye
• Known or suspected sensitivity or allergy to fluorescein dye
• Significant medial opacity (e.g. cataract) precluding clincial imaging adequate for interpretation
• Prior history of vitrectomy surger in potential study eye

Where it is running

• Duke Eye Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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